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Location - Entering Manually in the Sales
Order 
Normally, when a sales order is entered in CRM Enterprise, the location where the item is to be delivered from is determined automatically using location determination. (See also Location Determination in the Sales Order.)
However, in exceptional cases, you may need to overwrite the location, to specify that ATP check is carried out in this location first.
Other prerequisites are listed under Location in the Sales Order.
When ATP check is carried out, the manually entered location is checked before the other locations based on rules are checked.
You have to store location-dependent product master data for the product. For more information, see the SAP Library for SAP Supply Chain Management under Master Data ® Product ® Maintaining Location-Dependent Product Master Data.

You can change the location for main items only.
You cannot change the location if checked deliveries exist for the item or one of its subitems.
The location is represented in the sales transaction item as a business partner with the role Vendor on the Business Partner tab. If the system has already determined a location, overwrite it with the business partner for the new location. You can also enter the vendor in the sales order at item level.
You overwrite a location when you create or change a sales order by entering the relevant business parter for the partner function Vendor. In this case, ATP check is automatically triggered. You can enter a location on item level only.

Note that the input help for the business partners lists all business partners, and does not take into consideration whether a particular location is allowed for the product entered in the sales order item.

You can also ensure that the sales order items are shipped together from a single location by entering a consolidation location.
For more information, see Consolidation Location.