Creating RFC Destinations for Replication and Realignment (SAP CRM,
Application Client) 
Logon to the SAP CRM System.
Access the activity using one of the following navigation options:
Call transaction SM59.
In the SAP CRM IMG menu, choose .
Choose Create.
Enter the following data:
In the RFC Destination field, enter SAPCRM_MW_RR_<CRM client>.
In the Connection Type field, enter L.
In the Description field, enter Processing R&R queues – client <your CRM client>.
Choose Enter.
On the Logon & Security tab page, enter the following:
In the Client field, enter <your CRM client>.
In the User field, enter CRMMID2CRM.
In the Password field, enter <your password>.
Choose Enter.
On the Special Options tab page, enter the following:
Deselect the Slow RFC Connection indicator.
Deselect the Set RFC Trace indicator.
On the MDMP & Unicode select the Unicode indicator, if the target system is a Unicode system.
Save your entries.
Confirm the information message.
You can now test your newly created RFC connection using Test connection.