In addition to the general considerations that apply to all controls, you should also note the following:

In a WAN environment, you should use Desktop Office Integration with caution, especially if you will be loading documents from the R/3 application server or a web server connected to the WAN.

There is also no way of reducing the quantities of data with which Desktop Office Integration works. The exception to this are documents stored in the Business Document Server that do not often change: it is possible to cache these documents at the frontend.