You can configure more than one RFC connection between a TREX system and an SAP system.
More than one application in an SAP system should access the same TREX system. For organizational and performance reasons, each application should use a separate RFC connection. This means:
There is a separate RFC destination for each application in the SAP system.
There is a separate TREX RFC server for each application in the TREX system.
The graphic below depicts this constellation.