Clearing the SLD
Cache 
Many actions performed during configuration time require you to access System Landscape Directory content from the Integration Builder. To optimize performance, this content is loaded into a cache so that the Integration Builder does not have access the System Landscape Directory directly each time that content is required.
However, this cache is not automatically updated if changes are made to the content of the System Landscape Directory. For this reason, SAP recommends that you clear the System Landscape Directory cache if changes have been made to content in the System Landscape Directory. The cache is then filled each time that the System Landscape Directory is accessed.

Search help is offered when configuring receiver determinations. To optimize performance, the search help function accesses the cache instead of accessing the System Landscape Directory directly. When you create a business system in the System Landscape Directory, the information about the business system is not automatically transferred to the System Landscape Directory cache. For this reason, this business system is not displayed when the search help is called. Therefore, SAP recommends that you clear the System Landscape Directory cache so that the most up-to-date data from the System Landscape Directory is loaded into the cache.
To empty the SLD cache, from the Integration Builder main menu (configuration tool), choose Tools ® Empty SLD Cache.